JODY Rosenblatt

Professor of Cell Biology

Principal Investigator

JOHN Fadul

Research Associate

I did my PhD in Oncological Sciences with Dr. Stephen Lessnick at the University of Utah, where I studied the transcriptional regulation of cell identity in a pediatric sarcoma. Currently I investigate how cancer cells exploit basal cell extrusion to invade using the developing zebrafish skin as a model. We believe that a clearer understanding of the earliest metastatic steps would be pivotal in how we diagnose and treat malignancies. Outside the lab I enjoy nature, books, modern art, and yoga.

DUSTIN Bagley

Research Associate

TERESA Zulueta-Coarasa

EMBO and Marie Sklodowska Curie Postdoctoral Research Fellow

I originally hail from Salt Lake City, Utah where I completed my undergraduate work and doctoral training in the Molecular Biology PhD program at the University of Utah, under the supervision of Jerry Kaplan studying membrane trafficking and iron metabolism, in yeast and mammalian systems. I came to Jody’s lab as a postdoc at the Huntsman Cancer Institute in 2017 via Naples and Milan, where I worked in the groups of Andrea Ballabio and Pier Paolo Di Fiore studying the cellular and molecular mechanisms of genetic diseases in the context of autophagy and endocytosis. Currently, in Jody’s group, we are studying the mechanics of asthma focusing on the epithelium and the damage done to it by bronchoconstriction events using tissue culture, precision-cut ex vivo lung slices and mouse models, hoping to implement a novel therapeutic approach to an old problem.

I joined the Rosenblatt Lab after obtaining my PhD in Biomedical Engineering for work completed with Prof. Rodrigo Fernandez-Gonzalez at the University of Toronto. Currently, I am applying my skillset in bio-mechanics and quantitative image analysis to investigate how mechanical signals affect cancer cell spreading in vivo using the zebrafish embryo as a model organism. When I am not in the lab I enjoy film, video games, nature and cross-stich.

CARLOS Pardo-Pastor

Human Frontier Science Program Research Associate

I studied Human Biology, a MSc and my PhD at Universitat Pompeu Fabra (UPF), in a campus built, literally, on the beach in Barcelona. Following my interests on ion channels, mechanobiology and microscopy, I joined the Rosenblatt Lab to study how the mechanically-activated channel Piezo1 regulates cell cycle progression, migration and extrusion during homeostatic and aberrant epithelial turnover in response to mechanical inputs. Outside the lab I enjoy discovering London, reading or cooking, always with music or, lately, podcasts.

SARANNE Mitchell

PhD Candidate, University of Utah

Biomedical Engineering

Currently, I investigate biomechanical cues that may predict and drive cell extrusion at the individual cell level. Using mathematical programs and a variety of microscopy techniques including wide field, confocal, and quantitative phase I am able to explore mechanical cues in epithelial cell culture. When I am not researching, I enjoy skiing, painting, reading, and a good glass of wine.

NESHIKA Wijewardhane

MRes Student

Translational Cancer Medicine

After finishing my BSc in Cellular and Molecular Medicine at the University of Bristol, I joined the Rosenblatt lab for the first rotation of my Master’s programme. Senescent cells are known to accumulate and lead to the development of many age-related diseases, such as ageing and cancer. Therefore, I am exploring if senescent epithelial cells can be removed by cell extrusion. Outside of the lab, I like to read novels, watch tv series, bake and decorate cakes. 

Lily.png

LILY Gates

Research Technician &

MSci Student, Biochemistry

I joined the Rosenblatt lab as part of my MSci in Biochemistry, for my Third Year Research project at King's College London. During this time, I researched potential signalling pathways of epithelial cell extrusion. I enjoyed it so much that I am continuing the project, focusing on the role of autophagy in extrusion, as part of my Fourth Year Research project. In my spare time, I care for my cats, chickens, and dog, and if the tide is high, you will find me in the sea.  

 

Past members

 

Karolina Sek, undergraduate

Sabrina Bouhafs, undergraduate

Swapna Gudipaty, research associate and lab manager

Merry Joseph, undergraduate

Nadja Redd, undergraduate

Polly Redd, undergraduate

Franco Jin, undergraduate

Kaitlyn Fox, undergraduate

Danielle Hedeen, PhD student
Crystal Davey, postdoc

Kristina Fox, undergraduate

Conan Kinsey, postdoc

Gloria Slattum, PhD student and postdoc

George Eisenhoffer, postdoc

Yapeng Gu, postdoc

Thomas Marshall, postdoc

Jean-Marie Delalande, postdoc

Daniel Andrade-Sanchez, PhD student

Patrick Loftus, undergraduate

Jael Lindblom, MD fellow