Bronchoconstriction damages airway epithelia by crowding-induced excess cell extrusion. Bagley DC, Russell T, Ortiz-Zapater E, Stinson S, Fox K, Redd PF, Joseph M, Deering-Rice C, Reilly C, Parsons M, Brightling C, Rosenblatt J. Science. 2024 Apr 5;384(6691):66-73. doi: 10.1126/science.adk2758. Epub 2024 Apr 4. PMID: 38574138. pdf
Comment. Epithelial cells crowded out in asthma. Drazen JM, Fredberg JJ. Science. 2024 Apr 5;384(6691):30-31. doi: 10.1126/science.ado4514. Epub 2024 Apr 4. PMID: 38574157. pdf
The RNA binding proteins ZFP36L1 and ZFP36L2 are dysregulated in airway epithelium in human and a murine model of asthma. Rynne J, Ortiz-Zapater E, Bagley DC, Zanin O, Doherty G, Kanabar V, Ward J, Jackson DJ, Parsons M, Rosenblatt J, Adcock I, Martinez-Nunez RT. Front Cell Dev Biol. 2023 Oct 19. doi: 10.3389/fcell.2023.1241008. pdf
Piezo1 activates noncanonical EGFR endocytosis and signaling. Pardo-Pastor C, Rosenblatt J. Sci Adv. 2023 Sep 27; 9(39). doi: 10.1126/sciadv.adi1328. PMID: 37756411. pdf
Voltage-dependent volume regulation controls epithelial cell extrusion and morphology. Mitchell SJ, Pardo-Pastor C, Zangle TA, Rosenblatt J. bioRxiv. 2023 Mar 14. doi: 10.1101/2023.03.13.532421.
Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation. Ortiz-Zapater E, Bagley DC, Hernandez VL, Roberts LB, Maguire TJA, Voss F, Mertins P, Kirchner M, Peset-Martin I, Woszczek G, Rosenblatt J, Gotthardt M, Santis G, Parsons M. Nat Commun. 2022 Oct 27; 13(1):6407. doi: 10.1038/s41467-022-33882-w. PMID: 36302767. pdf
Physical confinement promotes mesenchymal trans-differentiation of invading transformed cells in vivo. Zulueta-Coarasa T, Fadul J, Ahmed M, Rosenblatt J. iScience. 2022 Oct 13. doi: 10.1016/j.isci.2022.105330. PMID: 36325066. pdf
KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion. Fadul J, Zulueta-Coarasa T, Slattum GM, Redd NM, Jin MF, Redd MJ, Daetwyler S, Hedeen D, Huisken J, Rosenblatt J. Nat Commun. 2021 Dec 10;12(1):7180. doi: 10.1038/s41467-021-27513-z. PMID: 34893591. pdf
The role of tissue maturity and mechanical state in controlling cell extrusion. Zulueta-Coarasa T, Rosenblatt J. Curr Opin Genet Dev. 2021 Sep 21;72:1-7. doi: 10.1016/j.gde.2021.09.003. PMID: 34560388. pdf
Early mechanical selection of cell extrusion and extrusion signaling in cancer. Mitchell SJ, Rosenblatt J. Curr Opin Cell Biol. 2021 Oct;72:36-40. doi: 10.1016/j.ceb.2021.04.005. Epub 2021 May 24. PMID: 34034216. pdf
Replication stress promotes cell elimination by extrusion. Dwivedi VK, Pardo-Pastor C, Droste R, Kong JN, Tucker N, Denning DP, Rosenblatt J, Horvitz HR. Nature. 2021; 593:591–596. doi: 10.1038/s41586-021-03526-y. PMID: 33953402. pdf
Unconventional Ways to Live and Die: Cell Death and Survival in Development, Homeostasis, and Disease. Gudipaty SA, Conner CM, Rosenblatt J, Montell DJ. Annu Rev Cell Dev Biol. 2018 Oct 6;34:311-332. doi: 10.1146/annurev-cellbio-100616-060748. Epub 2018 Aug 8. Review. PMID: 30089222. pdf
The forces and fates of extruding cells. Fadul J, Rosenblatt J. Curr Opin Cell Biol. 2018 Oct;54:66-71. doi: 10.1016/j.ceb.2018.04.007. Epub 2018 May 1. Review. PMID: 29727745. pdf
Endothelia extrude apoptotic cells to maintain a constant barrier. Mleynek TM, Redd M, Chan A, Gu Y, Li DY, Rosenblatt J. bioRxiv. 2018 Feb 21. pdf
Epithelial cell extrusion: Pathways and pathologies. Gudipaty SA, Rosenblatt J. Semin Cell Dev Biol. 2017 Jul;67:132-140. doi: 10.1016/j.semcdb.2016.05.010. Epub 2016 May 19. Review. PMID: 27212253. pdf
Mechanical stretch triggers rapid epithelial cell division through Piezo1. Gudipaty SA, Lindblom J, Loftus PD, Redd MJ, Edes K, Davey CF, Krishnegowda V, Rosenblatt J. Nature. 2017 Mar 2;543(7643):118-121. doi: 10.1038/nature21407. Epub 2017 Feb 15. PMID: 28199303. pdf
A toolbox to study epidermal cell types in zebrafish. Eisenhoffer GT, Slattum G, Ruiz OE, Otsuna H, Bryan CD, Lopez J, Wagner DS, Bonkowsky JL, Chien CB, Dorsky RI, Rosenblatt J. J Cell Sci. 2017 Jan 1;130(1):269-277. doi: 10.1242/jcs.184341. Epub 2016 May 5. PMID: 27149923. pdf
Defective apical extrusion signaling contributes to aggressive tumor hallmarks. Gu Y, Shea J, Slattum G, Firpo MA, Alexander M, Mulvihill SJ, Golubovskaya VM, Rosenblatt J. Elife. 2015 Jan 26;4:e04069. doi: 10.7554/eLife.04069. PMID: 25621765. pdf
Tumour cell invasion: an emerging role for basal epithelial cell extrusion. Slattum GM, Rosenblatt J. Nat Rev Cancer. 2014 Jul;14(7):495-501. doi: 10.1038/nrc3767. Epub 2014 Jun 19. Review. PMID: 24943812. pdf
Cells: Shaping tissues and organs. Rosenblatt J, Gartner Z. Mol Biol Cell. 2014 Mar;25(6):730. doi: 10.1091/mbc.E13-11-0670. PMID: 24626844. pdf
Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P. Slattum G, Gu Y, Sabbadini R, Rosenblatt J. Curr Biol. 2014 Jan 6;24(1):19-28. doi: 10.1016/j.cub.2013.11.029. Epub 2013 Dec 19. PMID: 24361067. pdf
Jody Rosenblatt: to extrude apically or basally, that is the question. Interview by Caitlin Sedwick. Rosenblatt J. J Cell Biol. 2013 Aug 19;202(4):602-3. doi: 10.1083/jcb.2024pi. PMID: 23960143. pdf
Bringing balance by force: live cell extrusion controls epithelial cell numbers. Eisenhoffer GT, Rosenblatt J. Trends Cell Biol. 2013 Apr;23(4):185-92. doi: 10.1016/j.tcb.2012.11.006. Epub 2012 Dec 28. Review. PMID: 23273931. pdf
Programmed cell death: a new way worms get rid of unwanted cells. Rosenblatt J. Curr Biol. 2012 Oct 9;22(19):R844-6. doi: 10.1016/j.cub.2012.08.013. PMID: 23058805. pdf
New emerging roles for epithelial cell extrusion. Gu Y, Rosenblatt J. Curr Opin Cell Biol. 2012 Dec;24(6):865-70. doi: 10.1016/j.ceb.2012.09.003. Epub 2012 Oct 5. Review. PMID: 23044222. pdf
Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. Eisenhoffer GT, Loftus PD, Yoshigi M, Otsuna H, Chien CB, Morcos PA, Rosenblatt J. Nature. 2012 Apr 15;484(7395):546-9. doi: 10.1038/nature10999. PMID: 22504183. pdf
The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium. Marshall TW, Lloyd IE, Delalande JM, Näthke I, Rosenblatt J. Mol Biol Cell. 2011 Nov;22(21):3962-70. doi: 10.1091/mbc.E11-05-0469. Epub 2011 Sep 7. PMID: 21900494. pdf
Live imaging of cell extrusion from the epidermis of developing zebrafish. Eisenhoffer GT, Rosenblatt J. J Vis Exp. 2011 Jun 27;(52). pii: 2689. doi: 10.3791/2689. PMID: 21730948. pdf
Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway. Gu Y, Forostyan T, Sabbadini R, Rosenblatt J. J Cell Biol. 2011 May 16;193(4):667-76. doi: 10.1083/jcb.201010075. Epub 2011 May 9. PMID: 21555463. pdf
Apoptotic regulation of epithelial cellular extrusion. Andrade D, Rosenblatt J. Apoptosis. 2011 May;16(5):491-501. doi: 10.1007/s10495-011-0587-z. PMID: 21399977. pdf
P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium. Slattum G, McGee KM, Rosenblatt J. J Cell Biol. 2009 Sep 7;186(5):693-702. doi: 10.1083/jcb.200903079. Epub 2009 Aug 31. PMID: 19720875. pdf
Mitosis: moesin and the importance of being round. Rosenblatt J. Curr Biol. 2008 Apr 8;18(7):R292-3. doi: 10.1016/j.cub.2008.02.013. PMID: 18397735. pdf
Spindle assembly: asters part their separate ways. Rosenblatt J. Nat Cell Biol. 2005 Mar;7(3):219-22. PMID: 15738974. pdf
Myosin II-dependent cortical movement is required for centrosome separation and positioning during mitotic spindle assembly. Rosenblatt J, Cramer LP, Baum B, McGee KM. Cell. 2004 Apr 30;117(3):361-72. PMID: 15109496. pdf
An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism. Rosenblatt J, Raff MC, Cramer LP. Curr Biol. 2001 Nov 27;11(23):1847-57. PMID: 11728307. pdf